PDRN Therapy (Polydeoxyribonucleotide): Advanced Skin Rejuvenation at Skin Nation Clinic, Delhi & Faridabad

Discover the science of natural skin regeneration

Modern aesthetic medicine is shifting towards regenerative and cellular-level therapies that rejuvenate the skin from within. Among the most effective of these is PDRN Therapy (Polydeoxyribonucleotide Therapy) — a scientifically backed treatment that improves texture, firmness, hydration, and glow by stimulating your skin’s natural healing process.

At Skination Clinic, led by Dr. Swati Agarwal and Dr. Rajat Gupta, both renowned dermatologists in Delhi-NCR, PDRN therapy is performed with international protocols and genuine medical-grade formulations. This treatment is ideal for anyone seeking long-term rejuvenation, fine line reduction, and overall improvement in skin health.

Polydeoxyribonucleotide (PDRN) is a DNA fragment derived primarily from salmon sperm. This may sound unusual, but the reason is scientific — salmon DNA has a high degree of similarity with human DNA, making it extremely biocompatible and safe for skin use.

PDRN consists of naturally occurring DNA polymers that serve as the building blocks for cell repair and regeneration. These DNA fragments act as messengers, signaling your body to heal, rebuild collagen, and restore damaged skin.

Other sources of PDRN

Although salmon DNA is most widely used (particularly in Korean and Italian formulations), research continues on alternative marine and recombinant synthetic sources that maintain the same regenerative properties.

Historical and scientific origin

PDRN was initially used in medical treatments for wound healing, burns, and tissue repair. Italian and Korean researchers were among the first to publish scientific evidence demonstrating PDRN’s ability to stimulate fibroblast activity and promote angiogenesis (formation of new blood vessels).

These discoveries opened the door to aesthetic applications, where PDRN injections rejuvenate, repair, and revitalize the skin from within.

Unlike fillers or Botox, PDRN doesn’t add volume or paralyze muscles. Instead, it works by reprogramming skin cells to act younger and healthier.

When injected into the dermis, PDRN:

                1.            Activates A2A Adenosine Receptors:

These receptors stimulate fibroblasts — the cells responsible for collagen and elastin synthesis.

                2.            Promotes Tissue Repair:

Damaged skin tissue begins self-repair, improving texture, tone, and elasticity.

                3.            Boosts Microcirculation:

It improves blood flow and oxygen delivery to the skin, enhancing radiance.

                4.            Reduces Inflammation:

It calms irritation and oxidative stress, making skin more resilient.

                5.            Improves DNA Repair:

As DNA fragments are absorbed, they encourage cell turnover and faster regeneration.

This multi-layered action gives visibly smoother, hydrated, and youthful skin within weeks.

PDRN is a powerhouse in aesthetic rejuvenation and offers several benefits:

                •             Deep hydration and improved skin moisture retention

                •             Reduction in fine lines, wrinkles, and early aging signs

                •             Smoother skin texture and smaller pores

                •             Brighter complexion and even skin tone

                •             Faster healing after lasers, peels, or microneedling

                •             Reduced redness and sensitivity in reactive skin

                •             Tightening and improved elasticity

                •             Healthier under-eye skin and fewer creases

                •             Enhanced collagen and elastin formation

Patients describe the results as a “glass-skin effect” — clear, luminous, and naturally plump.

PDRN therapy is suitable for both men and women looking to improve skin quality without surgery or fillers. It is ideal for:

                •             Dull or dehydrated skin

                •             Fine lines, wrinkles, or sagging

                •             Enlarged pores

                •             Uneven skin tone

                •             Post-acne scars or texture irregularities

                •             Sensitive or barrier-damaged skin

                •             Mild pigmentation or photoaging

                •             Early signs of aging on neck and hands

                •             Post-procedure skin recovery

Because PDRN acts at a cellular and DNA repair level, it benefits almost every skin type, including sensitive or acne-prone skin.

Our expert dermatologists ensure every session is customized to your skin’s condition and comfort level.

Step-by-Step Process

                1.            Comprehensive Consultation:

Your skin is analyzed using digital skin assessment tools to determine the treatment areas and session plan.

                2.            Cleansing and Numbing:

A mild cleanser and numbing cream are applied to ensure a pain-free experience.

                3.            Microinjection Technique:

PDRN is injected into the dermis through a fine needle or mesotherapy gun using microdroplet or linear threading technique for even distribution.

                4.            Cooling & Recovery Mask:

A soothing or hydrating mask may follow to calm the skin and lock in hydration.

                5.            Aftercare Guidance:

Post-care includes gentle cleansing, strict sun protection, and avoiding active products for 24–48 hours.

The entire session takes 30–45 minutes with minimal discomfort and virtually no downtime.

                •             Initial Course: 3–4 sessions spaced 3–4 weeks apart

                •             Maintenance: Once every 6–9 months

Results begin to show after the first or second session, and skin continues improving for several weeks as collagen remodeling occurs.

At Skin Nation Clinic, PDRN therapy can be customized or combined with advanced regenerative options for amplified benefits:

                •             PRP or GFC Therapy: Boosts growth factor synergy

                •             Exosome Therapy: Enhances cellular communication and recovery

                •             Microneedling or RF Microneedling: Improves absorption and collagen stimulation

                •             Laser Toning: Refines pigmentation and pores

                •             Hydrafacial or Mesotherapy: Provides pre-hydration before PDRN injection

Your dermatologist will recommend the ideal protocol depending on your aesthetic goals.

PDRN therapy has been clinically validated in multiple international studies for its regenerative potential. It has been used for over two decades in countries such as South Korea, Japan, Italy, Singapore, and Europe, both for medical and cosmetic purposes.

Safety Profile

                •             Non-immunogenic and sterile

                •             Suitable for all Fitzpatrick skin types

                •             Minimal side effects (mild redness or swelling for a few hours)

                •             No downtime or social restriction

Brands such as Rejuran Healer (South Korea), Hanheal (Korea), and Sesderma’s PDRN-based meso solutions (Spain) are FDA or CE approved in various countries for skin rejuvenation and wound healing.

At Skination, Dr. Swati Agarwal and Dr. Rajat Gupta often combine PDRN + PRP or Exosomes for comprehensive anti-aging and skin regeneration.

Most patients notice:

                •             Improved hydration and glow within 1–2 weeks

                •             Visible reduction in fine lines after 3–4 weeks

                •             Smoother texture and smaller pores by 6–8 weeks

                •             Progressive improvement over 2–3 months

With proper sun protection and maintenance, results last up to 9 months or longer.

Choosing the right clinic makes all the difference in results and safety.

Skination Clinic is recognized as one of the best dermatology clinics in Delhi and Faridabad, specializing in regenerative and anti-aging procedures.

What makes us different

                •             🧬 Authentic Korean & European PDRN products – Rejuran, Hanheal, and Sesderma

                •             🩺 Performed exclusively by dermatologists, not technicians

                •             💧 Combination approach for personalized rejuvenation

                •             🧖‍♀️ Comfort-focused procedure with premium numbing and post-care

                •             🌍 Global aesthetic standards and sterile environment

                •             🔬 Evidence-based protocols – Every treatment backed by clinical studies

                •             💬 Transparent consultation – realistic expectations and aftercare guidance

Patients from Delhi, Gurgaon, and Faridabad visit Skin Nation for advanced PDRN, GFC, Exosome, and PRP treatments because of the clinic’s strong medical ethics, natural-looking results, and patient satisfaction.

To maximize results:

                •             Avoid makeup or active skincare for 24 hours

                •             Use gentle cleansers and intense moisturizers

                •             Apply broad-spectrum sunscreen (SPF 50) daily

                •             Avoid saunas, steam, or workouts for 48 hours

                •             Stay hydrated and maintain a balanced diet rich in antioxidants

1. Is PDRN therapy painful?

Not at all. Numbing cream ensures a comfortable experience, and injections are very superficial.

2. Can I combine PDRN with Botox or fillers?

Yes, they target different skin layers and can complement each other beautifully.

3. Is PDRN safe for sensitive or acne-prone skin?

Yes, it has anti-inflammatory and healing effects, often improving skin sensitivity over time.

4. How long do the results last?

Typically 6–9 months, though maintenance sessions can extend benefits.

5. Are there side effects?

Mild redness or swelling that resolves within 12–24 hours. No long-term side effects reported.

6. Can men also take PDRN therapy?

Absolutely. PDRN works equally well for men seeking fresh, younger-looking skin without downtime.

7. Which brand of PDRN is used at Skin Nation?

We use clinically tested, authentic global brands like Rejuran Healer (South Korea), Hanheal (Korea), and Sesderma (Spain) for best efficacy and safety.

8. When can I resume normal activities?

You can go back to work the next day. Avoid heavy workouts or hot environments for one day.

9. Can it help open pores and texture?

Yes. PDRN visibly reduces pore size and refines texture through collagen remodeling.

10. Is PDRN a replacement for PRP?

Not exactly—it’s a complement. Many patients choose combination therapy for superior skin rejuvenation.

PDRN therapy represents the new era of natural skin rejuvenation — one that heals, repairs, and enhances your skin’s own potential instead of masking flaws.

If you’re searching for the best dermatology clinic in Delhi or Faridabad offering authentic PDRN, Rejuran, and regenerative aesthetic treatments, trust the expertise of Dr. Swati Agarwal and Dr. Rajat Gupta at Skin Nation Clinic.

Experience a visible transformation — smoother, brighter, and healthier skin that glows from within.